5jpz
From Proteopedia
(Difference between revisions)
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==Crystal structure of HAT domain of human Squamous Cell Carcinoma Antigen Recognized By T Cells 3, SART3 (TIP110)== | ==Crystal structure of HAT domain of human Squamous Cell Carcinoma Antigen Recognized By T Cells 3, SART3 (TIP110)== | ||
| - | <StructureSection load='5jpz' size='340' side='right' caption='[[5jpz]], [[Resolution|resolution]] 3.04Å' scene=''> | + | <StructureSection load='5jpz' size='340' side='right'caption='[[5jpz]], [[Resolution|resolution]] 3.04Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jpz]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5jpz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JPZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.045Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jpz OCA], [https://pdbe.org/5jpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jpz RCSB], [https://www.ebi.ac.uk/pdbsum/5jpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jpz ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:[https://omim.org/entry/175900 175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.<ref>PMID:15840095</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SART3_HUMAN SART3_HUMAN] Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.<ref>PMID:11959860</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Dreveny | + | [[Category: Large Structures]] |
| - | [[Category: Emsley | + | [[Category: Dreveny I]] |
| - | [[Category: Grazette | + | [[Category: Emsley J]] |
| - | [[Category: Harper | + | [[Category: Grazette A]] |
| - | [[Category: Layfield | + | [[Category: Harper S]] |
| - | + | [[Category: Layfield R]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of HAT domain of human Squamous Cell Carcinoma Antigen Recognized By T Cells 3, SART3 (TIP110)
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