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5jvd

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<StructureSection load='5jvd' size='340' side='right'caption='[[5jvd]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
<StructureSection load='5jvd' size='340' side='right'caption='[[5jvd]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jvd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JVD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JVD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jvd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JVD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NL:(2E)-3-(3-HYDROXY-4-METHOXYPHENYL)-1-(7-METHOXY-2H-1,3-BENZODIOXOL-5-YL)-2-METHYLPROP-2-EN-1-ONE'>6NL</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.393&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NL:(2E)-3-(3-HYDROXY-4-METHOXYPHENYL)-1-(7-METHOXY-2H-1,3-BENZODIOXOL-5-YL)-2-METHYLPROP-2-EN-1-ONE'>6NL</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jvd OCA], [http://pdbe.org/5jvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jvd RCSB], [http://www.ebi.ac.uk/pdbsum/5jvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jvd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jvd OCA], [https://pdbe.org/5jvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jvd RCSB], [https://www.ebi.ac.uk/pdbsum/5jvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jvd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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*[[User:Alisa Cario|User:Alisa Cario]]
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*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Buffalo rat]]
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[[Category: Gallus gallus]]
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[[Category: Chick]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bargsten, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Benkheil, M]]
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[[Category: Bargsten K]]
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[[Category: Bueno, O]]
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[[Category: Benkheil M]]
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[[Category: Camarasa, M J]]
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[[Category: Bueno O]]
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[[Category: Canela, M D]]
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[[Category: Camarasa M-J]]
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[[Category: Diaz, J F]]
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[[Category: Canela M-D]]
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[[Category: Jimeno, M L]]
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[[Category: Diaz JF]]
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[[Category: Liekens, S]]
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[[Category: Jimeno M-L]]
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[[Category: Noppen, S]]
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[[Category: Liekens S]]
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[[Category: Perez-Perez, M J]]
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[[Category: Noppen S]]
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[[Category: Priego, E M]]
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[[Category: Perez-Perez M-J]]
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[[Category: Prota, A E]]
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[[Category: Priego E-M]]
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[[Category: Ribatti, D]]
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[[Category: Prota AE]]
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[[Category: Saez-Calvo, G]]
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[[Category: Ribatti D]]
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[[Category: Steinmetz, M O]]
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[[Category: Saez-Calvo G]]
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[[Category: Velazquez, S]]
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[[Category: Steinmetz MO]]
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[[Category: Cell cycle]]
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[[Category: Velazquez S]]
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[[Category: Cytoskeleton]]
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[[Category: Microtubule]]
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[[Category: Tubulin fold]]
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Revision as of 19:10, 20 September 2023

Tubulin-TUB092 complex

PDB ID 5jvd

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