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5jxd

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Current revision (19:13, 20 September 2023) (edit) (undo)
 
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<StructureSection load='5jxd' size='340' side='right'caption='[[5jxd]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='5jxd' size='340' side='right'caption='[[5jxd]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JXD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.029&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxd OCA], [http://pdbe.org/5jxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jxd RCSB], [http://www.ebi.ac.uk/pdbsum/5jxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxd ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxd OCA], [https://pdbe.org/5jxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxd RCSB], [https://www.ebi.ac.uk/pdbsum/5jxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TFIP8_MOUSE TFIP8_MOUSE]] Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
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[https://www.uniprot.org/uniprot/TFIP8_MOUSE TFIP8_MOUSE] Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kim, M S]]
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[[Category: Mus musculus]]
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[[Category: Lee, D]]
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[[Category: Kim MS]]
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[[Category: Park, J]]
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[[Category: Lee D]]
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[[Category: Shin, D H]]
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[[Category: Park J]]
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[[Category: Immune system]]
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[[Category: Shin DH]]
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[[Category: Oxi-a]]
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[[Category: Phosphatidylethanolamine]]
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[[Category: Tnfaip8]]
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Current revision

Crystal structure of murine Tnfaip8 C165S mutant

PDB ID 5jxd

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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