5k0i

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Current revision (19:17, 20 September 2023) (edit) (undo)
 
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<StructureSection load='5k0i' size='340' side='right'caption='[[5k0i]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='5k0i' size='340' side='right'caption='[[5k0i]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5k0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K0I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5k0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K0I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PW:1,5-ANHYDRO-2,3,4-TRIDEOXY-3-{[(4S)-3,3-DIMETHYL-1-(8-METHYLQUINOLIN-2-YL)PIPERIDINE-4-CARBONYL]AMINO}-D-ERYTHRO-HEXITOL'>6PW</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PW:1,5-ANHYDRO-2,3,4-TRIDEOXY-3-{[(4S)-3,3-DIMETHYL-1-(8-METHYLQUINOLIN-2-YL)PIPERIDINE-4-CARBONYL]AMINO}-D-ERYTHRO-HEXITOL'>6PW</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGES, MGST1L1, MPGES1, PGES, PIG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0i OCA], [https://pdbe.org/5k0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k0i RCSB], [https://www.ebi.ac.uk/pdbsum/5k0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0i ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0i OCA], [http://pdbe.org/5k0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k0i RCSB], [http://www.ebi.ac.uk/pdbsum/5k0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0i ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
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[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Kuklish SL]]
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[[Category: Kuklish, S L]]
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[[Category: Luz JG]]
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[[Category: Luz, J G]]
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[[Category: Inflammation]]
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[[Category: Inhibitor]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Mpges1]]
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[[Category: Pain]]
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Current revision

mpges1 bound to an inhibitor

PDB ID 5k0i

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OCA

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