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1n0u

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[[Image:1n0u.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1n0u", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=SO1:[1R-(1.ALPHA.,3A.BETA.,4.BETA.,4A.BETA.,7.BETA.,7A.ALPHA.,8A.BETA.)]8A-[(6-DEOXY-4-O-METHYL-BETA-D-ALTROPYRANOSYLOXY)METHYL]-4-FORMYL-4,4A,5,6,7,7A,8,8A-OCTAHYDRO-7-METHYL-3-(1-METHYLETHYL)-1,4-METHANO-S-INDACENE-3A(1H)-CARBOXYLIC+ACID'>SO1</scene>
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{{STRUCTURE_1n0u| PDB=1n0u | SCENE= }}
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|RELATEDENTRY=[[1fnm|1FNM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n0u OCA], [http://www.ebi.ac.uk/pdbsum/1n0u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n0u RCSB]</span>
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'''Crystal structure of yeast elongation factor 2 in complex with sordarin'''
'''Crystal structure of yeast elongation factor 2 in complex with sordarin'''
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[[Category: Nissen, P.]]
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[[Category: Ortiz, P A.]]
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[[Category: cis-proline]]
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[[Category: g-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:56:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:46 2008''
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Revision as of 22:56, 2 May 2008

Image:1n0u.gif

Template:STRUCTURE 1n0u

Crystal structure of yeast elongation factor 2 in complex with sordarin


Overview

Two crystal structures of yeast translation elongation factor 2 (eEF2) were determined: the apo form at 2.9 A resolution and eEF2 in the presence of the translocation inhibitor sordarin at 2.1 A resolution. The overall conformation of apo eEF2 is similar to that of its prokaryotic homolog elongation factor G (EF-G) in complex with GDP. Upon sordarin binding, the three tRNA-mimicking C-terminal domains undergo substantial conformational changes, while the three N-terminal domains containing the nucleotide-binding site form an almost rigid unit. The conformation of eEF2 in complex with sordarin is entirely different from known conformations observed in crystal structures of EF-G or from cryo-EM studies of EF-G-70S complexes. The domain rearrangements induced by sordarin binding and the highly ordered drug-binding site observed in the eEF2-sordarin structure provide a high-resolution structural basis for the mechanism of sordarin inhibition. The two structures also emphasize the dynamic nature of the ribosomal translocase.

About this Structure

1N0U is a Single protein structure of sequence from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1N0U with [Elongation Factors]. Full crystallographic information is available from OCA.

Reference

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase., Jorgensen R, Ortiz PA, Carr-Schmid A, Nissen P, Kinzy TG, Andersen GR, Nat Struct Biol. 2003 May;10(5):379-85. PMID:12692531 Page seeded by OCA on Sat May 3 01:56:49 2008

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