1n0w
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1n0w.gif|left|200px]] | [[Image:1n0w.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1n0w", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1n0w| PDB=1n0w | SCENE= }} | |
| - | | | + | |
| - | | | + | |
| - | }} | + | |
'''Crystal structure of a RAD51-BRCA2 BRC repeat complex''' | '''Crystal structure of a RAD51-BRCA2 BRC repeat complex''' | ||
| Line 26: | Line 23: | ||
==Reference== | ==Reference== | ||
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex., Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR, Nature. 2002 Nov 21;420(6913):287-93. Epub 2002 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12442171 12442171] | Insights into DNA recombination from the structure of a RAD51-BRCA2 complex., Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR, Nature. 2002 Nov 21;420(6913):287-93. Epub 2002 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12442171 12442171] | ||
| - | [[Category: ]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 36: | Line 32: | ||
[[Category: Venkitaraman, A R.]] | [[Category: Venkitaraman, A R.]] | ||
[[Category: Yu, D S.]] | [[Category: Yu, D S.]] | ||
| - | [[Category: | + | [[Category: Breast cancer susceptibility]] |
| - | [[Category: | + | [[Category: Dna repair]] |
| - | [[Category: | + | [[Category: Homologous recombination]] |
| - | [[Category: | + | [[Category: Protein complex]] |
| - | [[Category: | + | [[Category: Reca-like atpase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:56:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:56, 2 May 2008
Crystal structure of a RAD51-BRCA2 BRC repeat complex
Contents |
Overview
The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase enzyme, in pathways for DNA repair by homologous recombination. We report here the structure of a complex between an evolutionarily conserved sequence in BRCA2 (the BRC repeat) and the RecA-homology domain of RAD51. The BRC repeat mimics a motif in RAD51 that serves as an interface for oligomerization between individual RAD51 monomers, thus enabling BRCA2 to control the assembly of the RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. The RAD51 oligomerization motif is highly conserved among RecA-like recombinases, highlighting a common evolutionary origin for the mechanism of nucleoprotein filament formation, mirrored in the BRC repeat. Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility.
Disease
Known disease associated with this structure: Breast cancer 2, early onset OMIM:[600185], Fanconi anemia, complementation group D1 OMIM:[600185], Pancreatic cancer OMIM:[600185], Prostate cancer OMIM:[600185], Wilms tumor OMIM:[600185], Breast cancer, male, susceptibility to OMIM:[600185]
About this Structure
1N0W is a Protein complex structure of sequences from [1] and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex., Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR, Nature. 2002 Nov 21;420(6913):287-93. Epub 2002 Nov 10. PMID:12442171 Page seeded by OCA on Sat May 3 01:56:52 2008
