8c3d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections== | |
| - | + | <StructureSection load='8c3d' size='340' side='right'caption='[[8c3d]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C3D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P6S:benzyl+hydrogen+carbonate'>P6S</scene></td></tr> |
| - | [[Category: Ewert | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c3d OCA], [https://pdbe.org/8c3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c3d RCSB], [https://www.ebi.ac.uk/pdbsum/8c3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c3d ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> |
| - | [[Category: Lieske | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Ewert W]] | ||
| + | [[Category: Falke S]] | ||
| + | [[Category: Guenther S]] | ||
| + | [[Category: Karnicar K]] | ||
| + | [[Category: Lieske J]] | ||
| + | [[Category: Lindic N]] | ||
| + | [[Category: Loboda J]] | ||
| + | [[Category: Meents A]] | ||
| + | [[Category: Reinke PYA]] | ||
| + | [[Category: Turk D]] | ||
| + | [[Category: Usenik A]] | ||
Current revision
Sulfonated Calpeptin is a promising drug candidate against SARS-CoV-2 infections
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Categories: Homo sapiens | Large Structures | Synthetic construct | Ewert W | Falke S | Guenther S | Karnicar K | Lieske J | Lindic N | Loboda J | Meents A | Reinke PYA | Turk D | Usenik A
