1n1m

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[[Image:1n1m.jpg|left|200px]]
[[Image:1n1m.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1n1m |SIZE=350|CAPTION= <scene name='initialview01'>1n1m</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1n1m", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A3M:2-AMINO-3-METHYL-1-PYRROLIDIN-1-YL-BUTAN-1-ONE'>A3M</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1n1m| PDB=1n1m | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1m OCA], [http://www.ebi.ac.uk/pdbsum/1n1m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n1m RCSB]</span>
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}}
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'''Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor'''
'''Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor'''
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[[Category: Wagtmann, N R.]]
[[Category: Wagtmann, N R.]]
[[Category: Wiberg, F C.]]
[[Category: Wiberg, F C.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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[[Category: dimer]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:03 2008''
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Revision as of 22:58, 2 May 2008

Image:1n1m.jpg

Template:STRUCTURE 1n1m

Human Dipeptidyl Peptidase IV/CD26 in complex with an inhibitor


Overview

Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines and neuropeptides. We have determined the 2.5 A structure of the extracellular region of DPP-IV in complex with the inhibitor valine-pyrrolidide. The catalytic site is located in a large cavity formed between the alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain. Both domains participate in inhibitor binding. The structure indicates how substrate specificity is achieved and reveals a new and unexpected opening to the active site.

About this Structure

1N1M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog., Rasmussen HB, Branner S, Wiberg FC, Wagtmann N, Nat Struct Biol. 2003 Jan;10(1):19-25. PMID:12483204 Page seeded by OCA on Sat May 3 01:58:36 2008

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OCA

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