1n1l

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[[Image:1n1l.jpg|left|200px]]
[[Image:1n1l.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1n1l |SIZE=350|CAPTION= <scene name='initialview01'>1n1l</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1n1l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=TRL:{1-[2-(1-FORMYL-PROPYL)-3-METHANESULFONYLAMINO-PYRROLIDINE-1-CARBONYL]-2-METHYL-PROPYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>TRL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= H STRAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
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-->
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|DOMAIN=
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{{STRUCTURE_1n1l| PDB=1n1l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1l OCA], [http://www.ebi.ac.uk/pdbsum/1n1l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n1l RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''
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[[Category: Slater, M J.]]
[[Category: Slater, M J.]]
[[Category: Somers, D O.N.]]
[[Category: Somers, D O.N.]]
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[[Category: cofactor peptide]]
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[[Category: Cofactor peptide]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: nonstructural protein]]
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[[Category: Nonstructural protein]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: viral protein]]
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[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:12 2008''
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Revision as of 22:58, 2 May 2008

Image:1n1l.jpg

Template:STRUCTURE 1n1l

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)


Overview

[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.

About this Structure

1N1L is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents., Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO, Org Lett. 2002 Dec 12;4(25):4479-82. PMID:12465917 Page seeded by OCA on Sat May 3 01:58:38 2008

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OCA

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