1n1o

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[[Image:1n1o.gif|left|200px]]
[[Image:1n1o.gif|left|200px]]
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{{Structure
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|PDB= 1n1o |SIZE=350|CAPTION= <scene name='initialview01'>1n1o</scene>, resolution 1.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1n1o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TFT:(L)-ALPHA-THREOFURANOSYL-THYMINE-3&#39;-MONOPHOSPHATE'>TFT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1n1o| PDB=1n1o | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1o OCA], [http://www.ebi.ac.uk/pdbsum/1n1o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n1o RCSB]</span>
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'''Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA'''
'''Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA'''
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==About this Structure==
==About this Structure==
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1N1O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1O OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1O OCA].
==Reference==
==Reference==
Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'--&gt;2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA., Wilds CJ, Wawrzak Z, Krishnamurthy R, Eschenmoser A, Egli M, J Am Chem Soc. 2002 Nov 20;124(46):13716-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12431101 12431101]
Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'--&gt;2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA., Wilds CJ, Wawrzak Z, Krishnamurthy R, Eschenmoser A, Egli M, J Am Chem Soc. 2002 Nov 20;124(46):13716-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12431101 12431101]
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[[Category: Protein complex]]
 
[[Category: Egli, M.]]
[[Category: Egli, M.]]
[[Category: Eschenmoser, A.]]
[[Category: Eschenmoser, A.]]
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[[Category: Wawrzak, Z.]]
[[Category: Wawrzak, Z.]]
[[Category: Wilds, C J.]]
[[Category: Wilds, C J.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: four-carbon sugar]]
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[[Category: Four-carbon sugar]]
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[[Category: hydrogen bonding]]
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[[Category: Hydrogen bonding]]
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[[Category: nucleic acid analogue]]
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[[Category: Nucleic acid analogue]]
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[[Category: nucleic acid etiology]]
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[[Category: Nucleic acid etiology]]
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[[Category: tetrose]]
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[[Category: Tetrose]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:04 2008''
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Revision as of 22:58, 2 May 2008

Image:1n1o.gif

Template:STRUCTURE 1n1o

Crystal Structure of a B-form DNA Duplex Containing (L)-alpha-threofuranosyl (3'-2') Nucleosides: A Four-Carbon Sugar is Easily Accommodated into the Backbone of DNA


Overview

(L)-alpha-Threofuranosyl-(3'-->2')-oligonucleotides (TNA) containing vicinally connected phosphodiester linkages undergo informational base pairing in an antiparallel strand orientation and are capable of cross-pairing with RNA and DNA. TNA is derived from a sugar containing only four carbon atoms and is one of the simplest potentially natural nucleic acid alternatives investigated thus far in the context of a chemical etiology of nucleic acid structure. Compared to DNA and RNA that contain six covalent bonds per repeating nucleotide unit, TNA contains only five. We have determined the atomic-resolution crystal structure of the B-form DNA duplex [d(CGCGAA)Td(TCGCG)](2) containing a single (L)-alpha-threofuranosyl thymine (T) per strand. In the modified duplex base stacking interactions are practically unchanged relative to the reference DNA structure. The orientations of the backbone at the TNA incorporation sites are slightly altered in order to accommodate fewer atoms and covalent bonds. The conformation of the threose is C4'-exo with the 2'- and 3'-substituents assuming quasi-diaxial orientation.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA., Wilds CJ, Wawrzak Z, Krishnamurthy R, Eschenmoser A, Egli M, J Am Chem Soc. 2002 Nov 20;124(46):13716-21. PMID:12431101 Page seeded by OCA on Sat May 3 01:58:47 2008

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