1n22

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[[Image:1n22.gif|left|200px]]
[[Image:1n22.gif|left|200px]]
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{{Structure
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|PDB= 1n22 |SIZE=350|CAPTION= <scene name='initialview01'>1n22</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1n22", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=7A8:(1R)-DIMETHYL-(4-METHYL-CYCLOHEX-3-ENYL)-AMINE'>7A8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Geranyl-diphosphate_cyclase Geranyl-diphosphate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.8 5.5.1.8] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1n22| PDB=1n22 | SCENE= }}
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|RELATEDENTRY=[[1n1b|1N1B]], [[1n1z|1N1Z]], [[1n20|1N20]], [[1n21|1N21]], [[1n23|1N23]], [[1n24|1N24]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n22 OCA], [http://www.ebi.ac.uk/pdbsum/1n22 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n22 RCSB]</span>
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}}
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'''(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene'''
'''(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene'''
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[[Category: Whittington, D A.]]
[[Category: Whittington, D A.]]
[[Category: Wise, M L.]]
[[Category: Wise, M L.]]
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[[Category: terpene synthase fold]]
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[[Category: Terpene synthase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:15 2008''
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Revision as of 22:59, 2 May 2008

Image:1n22.gif

Template:STRUCTURE 1n22

(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene


Overview

The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring monoterpene cyclase from Salvia officinalis, is reported at 2.0-A resolution. Each monomer contains two alpha-helical domains: the C-terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple reactive carbocation intermediates; the N-terminal domain has no clearly defined function, although its N terminus caps the active site in the C-terminal domain during catalysis. Structures of complexes with aza analogues of substrate and carbocation intermediates, as well as complexes with pyrophosphate and bornyl diphosphate, provide "snapshots" of the terpene cyclization cascade.

About this Structure

1N22 is a Single protein structure of sequence from Salvia officinalis. Full crystallographic information is available from OCA.

Reference

Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase., Whittington DA, Wise ML, Urbansky M, Coates RM, Croteau RB, Christianson DW, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15375-80. Epub 2002 Nov 13. PMID:12432096 Page seeded by OCA on Sat May 3 01:59:31 2008

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