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5kjm

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Current revision (10:02, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kjm' size='340' side='right'caption='[[5kjm]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='5kjm' size='340' side='right'caption='[[5kjm]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kjm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KJM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KJM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TM:6-[2-[4-[2-(3,4-DICHLOROPHENYL)ETHYL]PIPERAZIN-1-YL]PHENYL]-~{N}-(3-PYRROLIDIN-1-YLPROPYL)-2~{H}-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXAMIDE'>6TM</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kjk|5kjk]], [[5kjl|5kjl]], [[5kjn|5kjn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6TM:6-[2-[4-[2-(3,4-DICHLOROPHENYL)ETHYL]PIPERAZIN-1-YL]PHENYL]-~{N}-(3-PYRROLIDIN-1-YLPROPYL)-2~{H}-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXAMIDE'>6TM</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMYD2, KMT3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjm OCA], [https://pdbe.org/5kjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kjm RCSB], [https://www.ebi.ac.uk/pdbsum/5kjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjm OCA], [http://pdbe.org/5kjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kjm RCSB], [http://www.ebi.ac.uk/pdbsum/5kjm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
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[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ferguson, A]]
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[[Category: Ferguson A]]
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[[Category: Histone methyltransferase]]
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[[Category: Inhibitor]]
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[[Category: Tranferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

SMYD2 in complex with AZ931

PDB ID 5kjm

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OCA

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