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3a1g

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Current revision (10:29, 27 September 2023) (edit) (undo)
 
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<StructureSection load='3a1g' size='340' side='right'caption='[[3a1g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3a1g' size='340' side='right'caption='[[3a1g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a1g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/I34a1 I34a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a1g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1G FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ztt|2ztt]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211044 I34A1]), PB2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211044 I34A1])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1g OCA], [https://pdbe.org/3a1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1g RCSB], [https://www.ebi.ac.uk/pdbsum/3a1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1g OCA], [https://pdbe.org/3a1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1g RCSB], [https://www.ebi.ac.uk/pdbsum/3a1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RDRP_I34A1 RDRP_I34A1]] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription. [[https://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
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[https://www.uniprot.org/uniprot/RDRP_I34A1 RDRP_I34A1] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: I34a1]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Obayashi E]]
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[[Category: Obayashi, E]]
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[[Category: Park S-Y]]
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[[Category: Park, S Y]]
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[[Category: Sugiyama K]]
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[[Category: Sugiyama, K]]
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[[Category: Influenza virus]]
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[[Category: Mitochondrion]]
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[[Category: Mrna capping]]
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[[Category: Mrna processing]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Rna polymerase]]
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[[Category: Rna replication]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Transferase]]
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[[Category: Virion]]
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Current revision

High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus

PDB ID 3a1g

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