5kug

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Current revision (10:55, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kug' size='340' side='right'caption='[[5kug]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5kug' size='340' side='right'caption='[[5kug]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KUG FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kuj|5kuj]], [[5kui|5kui]], [[5kue|5kue]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCU, C10orf42, CCDC109A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kug OCA], [https://pdbe.org/5kug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kug RCSB], [https://www.ebi.ac.uk/pdbsum/5kug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kug ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kug OCA], [http://pdbe.org/5kug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kug RCSB], [http://www.ebi.ac.uk/pdbsum/5kug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kug ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MCU_HUMAN MCU_HUMAN]] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.<ref>PMID:21685886</ref> <ref>PMID:21685888</ref> <ref>PMID:22822213</ref> <ref>PMID:22829870</ref> <ref>PMID:22904319</ref> <ref>PMID:23101630</ref> <ref>PMID:23178883</ref> <ref>PMID:24332854</ref> <ref>PMID:24560927</ref>
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[https://www.uniprot.org/uniprot/MCU_HUMAN MCU_HUMAN] Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.<ref>PMID:21685886</ref> <ref>PMID:21685888</ref> <ref>PMID:22822213</ref> <ref>PMID:22829870</ref> <ref>PMID:22904319</ref> <ref>PMID:23101630</ref> <ref>PMID:23178883</ref> <ref>PMID:24332854</ref> <ref>PMID:24560927</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kug" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kug" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Junop, M S]]
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[[Category: Junop MS]]
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[[Category: Lee, S K]]
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[[Category: Lee SK]]
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[[Category: Mok, M C.Y]]
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[[Category: Mok MCY]]
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[[Category: Stathopulos, P B]]
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[[Category: Stathopulos PB]]
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[[Category: Beta-grasp fold n-terminal domain residues 72-189 mitochondrial calcium uniporter]]
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[[Category: Metal transport]]
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Current revision

Human mitochondrial calcium uniporter (residues 72-189) crystal structure with lithium

PDB ID 5kug

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