Serine/threonine protein kinase 3D structures

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3D structures of serine/threonine protein kinase

Updated on 03-October-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Serine/threonine_protein_kinase_3D_structures"

Category: Topic Page

@@ Line 14: / Line 14: @@
 **[[7akm]] - hChk1 kinase domain + ATP<br />
-**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]] - hChk1 kinase domain + inhibitor<br />
+**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]], [[8e80]] - hChk1 kinase domain + inhibitor<br />
 **[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7suh]], [[7sui]], [[7suj]]   - hChk1 kinase domain (mutant) + inhibitor<br />
 **[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
@@ Line 40: / Line 40: @@
 **[[4lgd]] – hChk3 kinase domain + RASSF5 SARAH domain<br />
 **[[6ao5]] – hChk3 kinase+SARAH domains (mutant) + SAV1 SARAH domain<br />
-**[[5dh3]] – hChk3 kinase domain + inhibitor<br />
+**[[5dh3]], [[8a66]] – hChk3 kinase domain + inhibitor<br />
 *'''Chk4 (Mst1)''' ); Domains – kinase 1-311; SARAH 432-480
 **[[3com]] – hChk4 kinase domain<br />
-**[[6yat]] – hChk4 kinase domain + inhibitor<br />
+**[[6yat]], [[8a5j]] – hChk4 kinase domain + inhibitor<br />
 **[[4nr2]] – hChk4 SARAH domain<br />
 **[[2jo8]] – hChk4 SARAH domain - NMR<br />
@@ Line 68: / Line 68: @@
 **[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
 **[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
-**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]] – hChk6 kinase domain + inhibitor<br />
+**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]], [[7ayh]], [[7ayi]], [[7fic]] – hChk6 kinase domain + inhibitor<br />
 **[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
 **[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
@@ Line 74: / Line 74: @@
 **[[5dn3]], [[5dos]], [[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor <br />
 **[[6c83]] – hChk6 kinase domain + AMPPCP + nanobody<br />
+**[[8sso]] – hChk6 kinase domain + drug + monobody<br />
 **[[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor <br />
-**[[5g1x]] – hChk6 kinase domain (mutant) + N-Myc <br />
+**[[5g1x]], [[7ztl]] – hChk6 kinase domain (mutant) + N-Myc <br />
+**[[8guw]] – hChk6 kinase domain/activator peptide <br />
 **[[5l8j]], [[5l8k]], [[5l8l]] – hChk6 kinase domain (mutant) + new antigen receptor variable domain <br />
 **[[5lxm]] – hChk6 kinase domain (mutant) + Targeting protein for XKLP2 <br />
@@ Line 118: / Line 120: @@
 *Plk1 Pbd complex with polypeptide
-**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]]  – hPlk1 + peptide<br />
+**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]], [[7mso]], [[7mx1]]  – hPlk1 + peptide<br />
 **[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]],  [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]], [[6gy2]] – hPlk1 + phosphopeptide<br />
 **[[1q4k]] – hPlk1 (mutant) + phosphopeptide<br />
@@ Line 129: / Line 131: @@
 *Plk1 Pbd complex with small molecule inhibitor
-**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]] – hPlk1 + inhibitor<br />
+**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]], [[8crc]] – hPlk1 + inhibitor<br />
 **[[2rku]] – hPlk1 (mutant) + inhibitor<br />
 **[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
@@ Line 162: / Line 164: @@
 **[[5lhy]] – hChk Plk4 Pb3 domain<br />
 **[[4yyp]], [[5lhz]] – hChk Plk4 Pb3 domain + Scl-interrupting locus protein <br />
-**[[4nk7]], [[4g7n]], [[5lhx]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
+**[[4nk7]], [[4g7n]], [[5lhx]], [[7rl3]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
 *'''Chk16'''
@@ Line 171: / Line 173: @@
 **[[3lm0]] – hChk17B  <br />
-**[[6qf4]] – hChk17B  + ADP<br />
+**[[6qf4]], [[7q7c]], [[7q7d]] – hChk17B  + ADP<br />
+**[[7q7e]] – hChk17B  + ATP<br />
 **[[3lm5]] – hChk17B  + quercetin<br />
 **[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B  + pyrimidine derivative<br />
 **[[7akg]] – hChk17B + drug<br />
-*'''Chk24 (Mst3)'''
+*'''Chk19''' or STK19
+**[[7xrb]] – hChk19  <br />
+*'''Chk24 (Mst3)''' or STK24
 **[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
-**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]] – hChk Mst3 + inhibitor <br />
+**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]], [[8bzi]] – hChk Mst3 + inhibitor <br />
 **[[3ckx]] – hChk24 kinase domain + staurosporin <br />
 **[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
@@ Line 227: / Line 234: @@
 **[[1unp]], [[1unr]] – hRac-α hChk pleckstrin homology domain <br />
-**[[2uzr]], [[2uzs]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
+**[[2uzr]], [[2uzs]], [[7myx]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
 **[[1h10]], [[1unq]], [[2uvm]] – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate<br />
 **[[3o96]], [[4ejn]], [[6s9w]], [[6s9x]], [[6hhj]], [[6hhi]], [[6hhh]], [[6hhg]], [[6hhf]] - hRac-α hChk + inhibitor<br />
@@ Line 260: / Line 267: @@
 *'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
-**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]] – hB-Raf kinase domain + anticancer drug<br />
+**[[8dgt]] – hB-Raf in Ras/Raf complex – Cryo EM<br />
+**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]], [[8f7o]], [[8f7p]] – hB-Raf kinase domain + anticancer drug<br />
 **[[1uwj]], [[6p3d]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
 **[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
 **[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
-**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]] - hB-Raf kinase domain + inhibitor<br />
+**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v], [[8c7y]]] - hB-Raf kinase domain + inhibitor<br />
 **[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br />
 **[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
+**[[8f7o]] – hB-Raf kinase domain + drug<br />
+**[[7m0u]] – hB-Raf kinase domain + AMPPNP + drug<br />
 **[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
 **[[7mfe]] – hB-Raf + 14-3-3 ζ/δ – Cryo EM<br />
@@ Line 299: / Line 309: @@
 **[[4g0n]], [[4g3x]] – hc-Raf RAS-binding domain + GTPase Hras <br />
 **[[3kud]] – hc-Raf RAS-binding domain (mutant) + GTPase Hras <br />
+**[[8epw]] – hc-Raf RAS-binding domain + GTPase Kras <br />
+**[[8atr]], [[8ats]], [[8avo]] – hc-Raf RAS-binding domain + 14-3-3 protein sigma <br />
 **[[6xgu]], [[6xgv]], [[6xha]], [[6xhb]] – hc-Raf RBD+CRD domains 52-188 + GTPase Kras + GMPPNP<br />
+**[[7z5r]], [[8gae]] – hc-Raf RBD domain + Hsp84 + Cdc37 + PP5 + ADP + ATP – Cryo EM<br />
+**[[7zr0]] – hc-Raf RBD domain + Hsp84 + Cdc37 + ATP – Cryo EM<br />
 *'''Snf1-related Chk'''
@@ Line 316: / Line 330: @@
 **[[6cj5]], [[6cje]], [[6cjh]], [[6cjw]], [[6cjy]], [[6ck3]], [[6ck6]], [[6cki]] – hMnk 2 catalytic domain (mutant) + inhibitor<br />
-*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; kinase 605-942
+*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; catalytic 109-426; kinase 605-942
 **[[1urf]] – hChk Pak-1 Hr1b domain - NMR<br />
@@ Line 340: / Line 354: @@
 **[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br />
 **[[5ved]] – hChk Pak-4 kinase domain + staurosporine<br />
+**[[8ahi]] – hChk Pak-4 300-591 + inhibitor<br />
+**[[7s46]], [[7s48]] – hChk Pak-4 catalytic domain + integrin beta-5 peptide<br />
 **[[2c30]] – hChk Pak-6<br />
 **[[2odb]] – hChk Pak-6 CRIB domain + CDC42<br />
@@ Line 367: / Line 383: @@
 **[[4y12]] - MtChk PknG + ATP-gS<br />
 **[[4y0x]] - MtChk PknG + ADP<br />
+**[[7q52]] - MtChk PknG + inhibitor<br />
 **[[4esq]] - MtChk PknH extracellular domain<br />
 **[[5m06]], [[5xka]] - MtChk  PknI kinase domain <br />
@@ Line 392: / Line 409: @@
 **[[6fdo]], [[6fdn]], [[6fdm]] – hChk Rio2 <br />
 **[[4otp]] – hChk Rio1 Rio domain + ADP <br />
-**[[6hk6]] – hChk Rio2 + inhibitor <br />
+**[[6hk6]], [[7vbt]] – hChk Rio2 + inhibitor <br />
 **[[6eml]], [[6fai]], [[6g18]], [[6g51]], [[6rbd]],[[6rbe]],  [[6y7c]] – yChk Rio2 in 40S particle – Cryo EM<br />
 **[[1ztf]] – AfChk Rio1 + adenine derivative – ''Archaeoglobus fulgidus''<br />
@@ Line 409: / Line 426: @@
 **[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]], [[6npn]], [[6vxu]], [[6vzh]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
 **[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
+**[[7tan]] – hChk Vrk1 kinase domain + nucleosome – Cryo EM<br />
 **[[2v62]] – hChk Vrk2 kinase domain <br />
-**[[5uu1]], [[6ncg]] – hChk Vrk2 kinase domain + inhibitor<br />
+**[[5uu1]], [[6ncg]], [[8q1z]] – hChk Vrk2 kinase domain + inhibitor<br />
 *Chk Wnk (protein kinase lysine-deficient); Domains - kinase 194-483; CCT1 454-549
@@ Line 424: / Line 442: @@
 **[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
 **[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
+**[[8edh]] - hChk Wnk3 kinase domain (mutant) + inhibitor<br />
 **[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
 **[[5w7t]] - rChk Wnk1 kinase domain <br />
@@ Line 496: / Line 515: @@
 **[[1aue]] – hFRAP FRB domain<BR />
 **[[2gaq]], [[2npu]] – hFRAP FRB domain - NMR<BR />
+**[[8ppz]] – hFRAP FRB domain + FKBP + pyridine derivative<BR />
 **[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
 **[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
@@ Line 518: / Line 538: @@
 **[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
 **[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
-**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]] – mTOR in mTor complex – Cryo EM <br />
+**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]], [[7uxc]], [[8era]] – mTOR in mTor complex – Cryo EM <br />
 *'''Gcn2'''
@@ Line 528: / Line 548: @@
 **[[1zyd]] – yChk Gcn2 + ATP<br />
 **[[4otn]] – mChk Gcn2 C terminal domain <br />
+*'''LRRK1''' or leucine-rich repeat Chk1
+**[[8e04]], [[8e05]], [[8e06]], [[8fac]] – hLRRK1 – Cryo EM <br />
 *'''LRRK2''' or leucine-rich repeat Chk2 or dardarin
@@ Line 534: / Line 558: @@
 **[[7lht]], [[7lhw]], [[7li4]] – hLRRK2 + ATP + GDP – Cryo EM <br />
 **[[7li3]] – hLRRK2 (mutant) + ATP + GDP – Cryo EM <br />
-**[[6oje]] – hLRRK2 GTPase domain 1329-1520<br />
+**[[6oje]], [[7thy]] – hLRRK2 GTPase domain 1329-1520<br />
 **[[6ojf]] – hLRRK2 GTPase domain (mutant) <br />
 **[[6dlo]], [[6dlp]] – hLRRK2 WD40 domain<br />
+**[[7thz]] – hLRRK2 1330-1527 + GDP <br />
 **[[6vno]], [[6vp6]], [[6vp7]] – hLRRK2 C terminal 1330-2527 – Cryo EM <br />
 **[[6vp8]] – hLRRK2 C terminal 1330-2527 + COR domain 1670-1950 + WD40 domain 2140-2489 – Cryo EM <br />
@@ Line 615: / Line 640: @@
 **[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
 **[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
+**[[8soi]], [[8sqz]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein<br />
+**[[8srm]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein – Cryo EM<br />
+**[[8srq]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein + PI3K – Cryo EM<br />
 **[[6qav]], [[6qau]], [[6qat]], [[6yid]] – hChk Ulk2 + inhibitor<br />
 **[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
@@ Line 685: / Line 713: @@
 *Other Chk complexes
-**[[1wbp]] – hChk Sprk1 + peptide<br />
+**[[1wbp]], [[7dd1]] – hChk Sprk1 + peptide<br />
 **[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
 **[[3hdm]], [[3hdn]], [[7pue]] – hChk Sgk1 (mutant) + inhibitor <br />
@@ Line 725: / Line 753: @@
 **[[6s8f]] – yChk Tel1 + AMPPNP – Cryo EM<br />
 **[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
-**[[5x6o]], [[6z3a]] – yChk Mec1 + LCD1 – Cryo EM<br />
+**[[5x6o]], [[6z3a]], [[7wzr]], [[7wzw]] – yChk Mec1 + LCD1 – Cryo EM<br />
 **[[6z2w]], [[6z2x]] – yChk Mec1 (mutant) + LCD1 – Cryo EM<br />
 **[[7kue]] – yChk Kin28 in TFIIK complex – Cryo EM<br />

Serine/threonine protein kinase 3D structures

From Proteopedia

Revision as of 09:52, 3 October 2023

3D structures of serine/threonine protein kinase

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