8bfw

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'''Unreleased structure'''
 
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The entry 8bfw is ON HOLD
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==The structures of Ace2 in complex with bicyclic peptide inhibitor==
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<StructureSection load='8bfw' size='340' side='right'caption='[[8bfw]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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Authors: Brear, P., Lulla, A., Harman, M., Dods, R., Chen, L., Bezerra, G., Demydchuk, Y., Stanway, S., Hyvonen, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bfw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BFW FirstGlance]. <br>
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Description: The structures of Ace2 in complex with bicyclic peptide inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFI:1-[3,5-bis(3-bromanylpropanoyl)-1,3,5-triazinan-1-yl]-3-bromanyl-propan-1-one'>LFI</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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[[Category: Stanway, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bfw OCA], [https://pdbe.org/8bfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bfw RCSB], [https://www.ebi.ac.uk/pdbsum/8bfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bfw ProSAT]</span></td></tr>
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[[Category: Hyvonen, M]]
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</table>
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[[Category: Bezerra, G]]
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== Function ==
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[[Category: Demydchuk, Y]]
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[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
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[[Category: Harman, M]]
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== References ==
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[[Category: Brear, P]]
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<references/>
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[[Category: Lulla, A]]
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__TOC__
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[[Category: Chen, L]]
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</StructureSection>
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[[Category: Dods, R]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Bezerra G]]
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[[Category: Brear P]]
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[[Category: Chen L]]
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[[Category: Demydchuk Y]]
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[[Category: Dods R]]
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[[Category: Harman M]]
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[[Category: Hyvonen M]]
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[[Category: Lulla A]]
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[[Category: Stanway S]]

Revision as of 12:30, 4 October 2023

The structures of Ace2 in complex with bicyclic peptide inhibitor

PDB ID 8bfw

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