This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8fr7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==A hinge glycan regulates spike bending and impacts coronavirus infectivity== | |
| - | + | <StructureSection load='8fr7' size='340' side='right'caption='[[8fr7]], [[Resolution|resolution]] 3.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fr7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_NL63 Human coronavirus NL63]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FR7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fr7 OCA], [https://pdbe.org/8fr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fr7 RCSB], [https://www.ebi.ac.uk/pdbsum/8fr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fr7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Chiu | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/SPIKE_CVHNL SPIKE_CVHNL] S1 region attaches the virion to the cell membrane by interacting with human ACE2, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Pintilie | + | </StructureSection> |
| - | [[Category: Schmid | + | [[Category: Human coronavirus NL63]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Chen M]] | ||
| + | [[Category: Chiu W]] | ||
| + | [[Category: Chmielewski D]] | ||
| + | [[Category: Jin J]] | ||
| + | [[Category: Pintilie G]] | ||
| + | [[Category: Schmid MF]] | ||
| + | [[Category: Singharoy A]] | ||
| + | [[Category: Wilson E]] | ||
Current revision
A hinge glycan regulates spike bending and impacts coronavirus infectivity
| |||||||||||
Categories: Human coronavirus NL63 | Large Structures | Chen M | Chiu W | Chmielewski D | Jin J | Pintilie G | Schmid MF | Singharoy A | Wilson E
