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| | ==Crystal Structure of NP2-B17 TCR-H2Db-NP complex== | | ==Crystal Structure of NP2-B17 TCR-H2Db-NP complex== |
| - | <StructureSection load='5sws' size='340' side='right' caption='[[5sws]], [[Resolution|resolution]] 2.86Å' scene=''> | + | <StructureSection load='5sws' size='340' side='right'caption='[[5sws]], [[Resolution|resolution]] 2.86Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5sws]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5SWS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5sws]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SWS FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5swz|5swz]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5sws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sws OCA], [https://pdbe.org/5sws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5sws RCSB], [https://www.ebi.ac.uk/pdbsum/5sws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5sws ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5sws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5sws OCA], [http://pdbe.org/5sws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5sws RCSB], [http://www.ebi.ac.uk/pdbsum/5sws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5sws ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 5sws" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 5sws" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Large Structures]] |
| - | [[Category: Campo, C M.Del]] | + | [[Category: Mus musculus]] |
| - | [[Category: Farenc, C]] | + | [[Category: Unidentified influenza virus]] |
| - | [[Category: Gras, S]] | + | [[Category: Del Campo CM]] |
| - | [[Category: Josephs, T M]] | + | [[Category: Farenc C]] |
| - | [[Category: Rossjohn, J]] | + | [[Category: Gras S]] |
| - | [[Category: H2db]] | + | [[Category: Josephs TM]] |
| - | [[Category: Immune system]] | + | [[Category: Rossjohn J]] |
| - | [[Category: Influenza]]
| + | |
| - | [[Category: Naive t cell]]
| + | |
| - | [[Category: Np1-b17 tcr]]
| + | |
| - | [[Category: Np366]]
| + | |
| - | [[Category: Reversed docking]]
| + | |
| - | [[Category: T cell]]
| + | |
| - | [[Category: Tcr]]
| + | |
| Structural highlights
Function
HA11_MOUSE Involved in the presentation of foreign antigens to the immune system.
Publication Abstract from PubMed
The anti-viral T cell response is drawn from the naive T cell repertoire. During influenza infection, the CD8+ T cell response to an H-2Db-restricted nucleoprotein epitope (NP366) is characterized by preferential expansion of T cells bearing TRBV13+ T cell receptors (TCRs) and avoidance of TRBV17+ T cells, despite the latter dominating the naive precursor repertoire. We found two TRBV17+ TCRs that bound H-2Db-NP366 with a 180 degrees reversed polarity compared to the canonical TCR-pMHC-I docking. The TRBV17 beta-chain dominated the interaction and, whereas the complementarity determining region-3 (CDR3) loops exclusively mediated contacts with the MHC-I, peptide specificity was attributable to germline-encoded recognition. Nevertheless, the TRBV17+ TCR exhibited moderate affinity toward H-2Db-NP366 and was capable of signal transduction. Thus, the naive CD8+ T cell pool can comprise TCRs adopting reversed pMHC-I docking modes that limit their involvement in the immune response.
Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.,Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XY, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL Immunity. 2016 Oct 18;45(4):749-760. doi: 10.1016/j.immuni.2016.09.007. Epub 2016, Oct 4. PMID:27717799[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XY, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL. Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response. Immunity. 2016 Oct 18;45(4):749-760. doi: 10.1016/j.immuni.2016.09.007. Epub 2016, Oct 4. PMID:27717799 doi:http://dx.doi.org/10.1016/j.immuni.2016.09.007
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