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5tci

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Current revision (12:57, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5tci' size='340' side='right'caption='[[5tci]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='5tci' size='340' side='right'caption='[[5tci]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tci]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tci]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TCI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79V:(2R,3S,4R)-3-(2-fluoro[1,1-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile'>79V</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79V:(2R,3S,4R)-3-(2-fluoro[1,1-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile'>79V</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5tcf|5tcf]], [[5tcg|5tcg]], [[5tch|5tch]], [[5tcj|5tcj]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trpA, Rv1613, MTCY01B2.05 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), trpB, Rv1612, MTCY01B2.04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tci OCA], [https://pdbe.org/5tci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tci RCSB], [https://www.ebi.ac.uk/pdbsum/5tci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tci ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tci OCA], [https://pdbe.org/5tci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tci RCSB], [https://www.ebi.ac.uk/pdbsum/5tci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tci ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[https://www.uniprot.org/uniprot/TRPB_MYCTU TRPB_MYCTU]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine (By similarity).
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[https://www.uniprot.org/uniprot/TRPA_MYCTU TRPA_MYCTU] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Tryptophan synthase]]
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[[Category: Fisher SL]]
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[[Category: Structural genomic]]
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[[Category: Hung DT]]
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[[Category: Fisher, S L]]
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[[Category: Jedrzejczak R]]
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[[Category: Hung, D T]]
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[[Category: Joachimiak A]]
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[[Category: Jedrzejczak, R]]
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[[Category: Maltseva N]]
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[[Category: Joachimiak, A]]
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[[Category: Michalska K]]
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[[Category: Maltseva, N]]
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[[Category: Nag PP]]
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[[Category: Michalska, K]]
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[[Category: Schreiber SL]]
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[[Category: Nag, P P]]
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[[Category: Wellington S]]
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[[Category: Schreiber, S L]]
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[[Category: Wellington, S]]
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[[Category: Allostery]]
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[[Category: Amino acid biosynthesis]]
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[[Category: Csgid]]
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[[Category: Heterotetramer]]
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[[Category: Lyase]]
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[[Category: Plp]]
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[[Category: Substrate channeling]]
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Current revision

Crystal structure of tryptophan synthase from M. tuberculosis - BRD4592-bound form

PDB ID 5tci

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