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1w51

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(New page: 200px<br /> <applet load="1w51" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w51, resolution 2.55&Aring;" /> '''BACE (BETA SECRETAS...)
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Revision as of 16:17, 29 October 2007

Image:1w51.gif

1w51, resolution 2.55Å

Drag the structure with the mouse to rotate

BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR

Overview

Human BACE, also known as beta-secretase, shows promise as a potential, therapeutic target for Alzheimer's disease. We determined the apo, structure of BACE to 1.75 A, and a structure of a hydroxyethylamine, inhibitor complex derived by soaking. These show significant active-site, movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by, structure-based drug design.

About this Structure

1W51 is a [Single protein] structure of sequence from [Homo sapiens] with IOD and L01 as [ligands]. Active as [[1]], with EC number [3.4.23.46]. Full crystallographic information is available from [OCA].

Reference

Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669

Page seeded by OCA on Mon Oct 29 18:21:47 2007

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