This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5u27

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:18, 4 October 2023) (edit) (undo)
 
Line 1: Line 1:
==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor==
==Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor==
-
<StructureSection load='5u27' size='340' side='right' caption='[[5u27]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
+
<StructureSection load='5u27' size='340' side='right'caption='[[5u27]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5u27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U27 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5u27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U27 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, folA_1, BN1213_03327, BN1303_00864, ERS007661_02580, ERS007663_03946, ERS007665_02766, ERS007741_00337, ERS013471_00736, ERS023446_01268, ERS024213_02711, ERS027644_04978, ERS027646_03318, ERS027653_04780, ERS027654_00299, ERS027656_00246, ERS027659_04151, ERS027661_03595, ERS027666_04095, ERS031537_04020, ERS124361_01473, RN05_2938 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=P65:2,4-DIAMINO-6-METHYL-5-[3-(2,4,5-TRICHLOROPHENOXY)PROPYLOXY]PYRIMIDINE'>P65</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u27 OCA], [https://pdbe.org/5u27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u27 RCSB], [https://www.ebi.ac.uk/pdbsum/5u27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u27 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u27 OCA], [http://pdbe.org/5u27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u27 RCSB], [http://www.ebi.ac.uk/pdbsum/5u27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u27 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/A0A0E8UVJ4_MYCTX A0A0E8UVJ4_MYCTX]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
+
[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 +
 
 +
==See Also==
 +
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Dihydrofolate reductase]]
+
[[Category: Large Structures]]
-
[[Category: Structural genomic]]
+
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Folate]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Ssgcid]]
+

Current revision

Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor

PDB ID 5u27

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5u27"
Personal tools