1n6j
From Proteopedia
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[[Image:1n6j.gif|left|200px]] | [[Image:1n6j.gif|left|200px]] | ||
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'''Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2''' | '''Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2''' | ||
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[[Category: Stroud, J C.]] | [[Category: Stroud, J C.]] | ||
[[Category: Youn, H D.]] | [[Category: Youn, H D.]] | ||
| - | [[Category: | + | [[Category: Histone deacetylase]] |
| - | [[Category: | + | [[Category: Mads-box]] |
| - | [[Category: | + | [[Category: Protein-dna complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:09:31 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:09, 2 May 2008
Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2
Overview
The myocyte enhancer factor-2 (MEF2) family of transcription factors has important roles in the development and function of T cells, neuronal cells and muscle cells. MEF2 is capable of repressing or activating transcription by association with a variety of co-repressors or co-activators in a calcium-dependent manner. Transcriptional repression by MEF2 has attracted particular attention because of its potential role in hypertrophic responses of cardiomyocytes. Several MEF2 co-repressors, such as Cabin1/Cain and class II histone deacetylases (HDACs), have been identified. However, the molecular mechanism of their recruitment to specific promoters by MEF2 remains largely unknown. Here we report a crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution. The crystal structure reveals a stably folded MEF2S domain on the surface of the MADS box. Cabin1 adopts an amphipathic alpha-helix to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Our studies of the ternary Cabin1/MEF2/DNA complex show a general mechanism by which MEF2 recruits transcriptional co-repressor Cabin1 and class II HDACs to specific DNA sites.
About this Structure
1N6J is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2., Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L, Nature. 2003 Apr 17;422(6933):730-4. PMID:12700764 Page seeded by OCA on Sat May 3 02:09:31 2008
