5uos

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Current revision (13:31, 4 October 2023) (edit) (undo)
 
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==Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12==
==Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12==
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<StructureSection load='5uos' size='340' side='right' caption='[[5uos]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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<StructureSection load='5uos' size='340' side='right'caption='[[5uos]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UOS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=171:2-PHENYLAMINO-ETHANESULFONIC+ACID'>171</scene>, <scene name='pdbligand=8FS:1-ethynyl-2,4-difluorobenzene'>8FS</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMACHC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=171:2-PHENYLAMINO-ETHANESULFONIC+ACID'>171</scene>, <scene name='pdbligand=8FS:1-ethynyl-2,4-difluorobenzene'>8FS</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uos OCA], [http://pdbe.org/5uos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uos RCSB], [http://www.ebi.ac.uk/pdbsum/5uos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uos ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uos OCA], [https://pdbe.org/5uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uos RCSB], [https://www.ebi.ac.uk/pdbsum/5uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uos ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN]] Methylmalonic acidemia with homocystinuria, type cblC. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN] Methylmalonic acidemia with homocystinuria, type cblC. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN]] May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
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[https://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN] May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Banerjee, R]]
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[[Category: Large Structures]]
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[[Category: Karasik, A]]
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[[Category: Banerjee R]]
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[[Category: Koutmos, M]]
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[[Category: Karasik A]]
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[[Category: Krautler, B]]
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[[Category: Koutmos M]]
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[[Category: Ruetz, M]]
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[[Category: Krautler B]]
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[[Category: Shanmuganathan, A]]
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[[Category: Ruetz M]]
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[[Category: B12 binding]]
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[[Category: Shanmuganathan A]]
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[[Category: B12 processing]]
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[[Category: B12 trafficking]]
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[[Category: Oxidoreductase]]
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[[Category: Vitamin b12]]
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Current revision

Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12

PDB ID 5uos

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