This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5upv
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5upv' size='340' side='right'caption='[[5upv]], [[Resolution|resolution]] 1.63Å' scene=''> | <StructureSection load='5upv' size='340' side='right'caption='[[5upv]], [[Resolution|resolution]] 1.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5upv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5upv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UPV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5upv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upv OCA], [https://pdbe.org/5upv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5upv RCSB], [https://www.ebi.ac.uk/pdbsum/5upv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5upv ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] |
==See Also== | ==See Also== | ||
| Line 17: | Line 15: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: IMP dehydrogenase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: Anderson | + | [[Category: Anderson WF]] |
| - | + | [[Category: Gu M]] | |
| - | [[Category: Gu | + | [[Category: Joachimiak A]] |
| - | [[Category: Joachimiak | + | [[Category: Kim Y]] |
| - | [[Category: Kim | + | [[Category: Makowska-Grzyska M]] |
| - | [[Category: Makowska-Grzyska | + | [[Category: Maltseva N]] |
| - | [[Category: Maltseva | + | [[Category: Mulligan R]] |
| - | [[Category: Mulligan | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36
| |||||||||||
