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5v5z

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Current revision (13:42, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5v5z' size='340' side='right'caption='[[5v5z]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5v5z' size='340' side='right'caption='[[5v5z]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5v5z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5v5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V5Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1YN:2-[(2R)-BUTAN-2-YL]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZIN-1-YL]PHENYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>1YN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jlc|5jlc]], [[5eqb|5eqb]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1YN:2-[(2R)-BUTAN-2-YL]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZIN-1-YL]PHENYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>1YN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERG11, CYP51, ERG16, CAALFM_C500660CA, CaO19.922 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5z OCA], [https://pdbe.org/5v5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v5z RCSB], [https://www.ebi.ac.uk/pdbsum/5v5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5z ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5z OCA], [http://pdbe.org/5v5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5z RCSB], [http://www.ebi.ac.uk/pdbsum/5v5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP51_CANAL CP51_CANAL]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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[https://www.uniprot.org/uniprot/CP51_CANAL CP51_CANAL] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5v5z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5v5z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canal]]
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[[Category: Candida albicans SC5314]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sterol 14-demethylase]]
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[[Category: Keniya MV]]
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[[Category: Keniya, M V]]
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[[Category: Monk BC]]
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[[Category: Monk, B C]]
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[[Category: Sabherwal M]]
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[[Category: Sabherwal, M]]
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[[Category: Sagatova AA]]
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[[Category: Sagatova, A A]]
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[[Category: Tyndall JDA]]
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[[Category: Tyndall, J D.A]]
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[[Category: Wilson RK]]
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[[Category: Wilson, R K]]
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[[Category: Candida albican]]
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[[Category: Cyp51]]
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[[Category: Itraconazole]]
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[[Category: Oxidoreductase-oxidoreducatse inhibitor complex]]
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[[Category: Pathogen]]
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Current revision

Structure of CYP51 from the pathogen Candida albicans

PDB ID 5v5z

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