1n7j

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[[Image:1n7j.jpg|left|200px]]
[[Image:1n7j.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1n7j |SIZE=350|CAPTION= <scene name='initialview01'>1n7j</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1n7j", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IDI:7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE'>IDI</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PNMT OR PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1n7j| PDB=1n7j | SCENE= }}
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|RELATEDENTRY=[[1hnn|1HNN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7j OCA], [http://www.ebi.ac.uk/pdbsum/1n7j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n7j RCSB]</span>
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}}
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'''The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor'''
'''The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor'''
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[[Category: McLeish, M J.]]
[[Category: McLeish, M J.]]
[[Category: McMillan, F M.]]
[[Category: McMillan, F M.]]
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[[Category: adrenaline]]
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[[Category: Adrenaline]]
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[[Category: catecholamine]]
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[[Category: Catecholamine]]
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[[Category: epinephrine]]
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[[Category: Epinephrine]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: s-adenolsylhomocysteine]]
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[[Category: S-adenolsylhomocysteine]]
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[[Category: s-adenosylmethionine]]
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[[Category: S-adenosylmethionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:11:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:27 2008''
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Revision as of 23:11, 2 May 2008

Image:1n7j.jpg

Template:STRUCTURE 1n7j

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor


Overview

The crystal structures of human phenylethanolamine N-methyltransferase in complex with S-adenosyl-l-homocysteine (7, AdoHcy) and either 7-iodo-1,2,3,4-tetrahydroisoquinoline (2) or 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine (3, LY134046) were determined and compared with the structure of the enzyme complex with 7 and 7-aminosulfonyl-1,2,3,4-tetrahydroisoquinoline (1, SK&F 29661). The enzyme is able to accommodate a variety of chemically disparate functional groups on the aromatic ring of the inhibitors through adaptation of the binding pocket for this substituent and by subtle adjustments of the orientation of the inhibitors within the relatively planar binding site. In addition, the interactions formed by the amine nitrogen of all three inhibitors reinforce the hypothesis that this functional group mimics the beta-hydroxyl of norepinephrine rather than the amine. These studies provide further clues for the development of improved inhibitors for use as pharmacological probes.

About this Structure

1N7J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase., McMillan FM, Archbold J, McLeish MJ, Caine JM, Criscione KR, Grunewald GL, Martin JL, J Med Chem. 2004 Jan 1;47(1):37-44. PMID:14695818 Page seeded by OCA on Sat May 3 02:11:35 2008

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