1n7u
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1n7u.jpg|left|200px]] | [[Image:1n7u.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1n7u", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1n7u| PDB=1n7u | SCENE= }} | |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''THE RECEPTOR-BINDING PROTEIN P2 OF BACTERIOPHAGE PRD1: CRYSTAL FORM I''' | '''THE RECEPTOR-BINDING PROTEIN P2 OF BACTERIOPHAGE PRD1: CRYSTAL FORM I''' | ||
| Line 30: | Line 27: | ||
[[Category: Butcher, S J.]] | [[Category: Butcher, S J.]] | ||
[[Category: Xu, L.]] | [[Category: Xu, L.]] | ||
| - | [[Category: | + | [[Category: Antibiotic-resistance]] |
| - | [[Category: | + | [[Category: Bacteriophage prd1]] |
| - | [[Category: | + | [[Category: Beta-propeller]] |
| - | [[Category: | + | [[Category: Proline-rich]] |
| - | [[Category: | + | [[Category: Viral receptor-binding]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:12:12 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:12, 2 May 2008
THE RECEPTOR-BINDING PROTEIN P2 OF BACTERIOPHAGE PRD1: CRYSTAL FORM I
Overview
Bacteriophage PRD1 is unusual, with an internal lipid membrane, but has striking resemblances to adenovirus that include receptor binding spikes. The PRD1 vertex complex contains P2, a 590 residue monomer that binds to receptors on antibiotic-resistant strains of E. coli and so is the functional counterpart to adenovirus fiber. P2 structures from two crystal forms, at 2.2 and 2.4 A resolution, reveal an elongated club-shaped molecule with a novel beta propeller "head" showing pseudo-6-fold symmetry. An extended loop with another novel fold forms a long "tail" containing a protruding proline-rich "fin." The head and fin structures are well suited to recognition and attachment, and the tail is likely to trigger the processes of vertex disassembly, membrane tube formation, and subsequent DNA injection.
About this Structure
1N7U is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.
Reference
The receptor binding protein P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has a novel fold suggesting multiple functions., Xu L, Benson SD, Butcher SJ, Bamford DH, Burnett RM, Structure. 2003 Mar;11(3):309-22. PMID:12623018 Page seeded by OCA on Sat May 3 02:12:12 2008
