5vxl
From Proteopedia
(Difference between revisions)
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<StructureSection load='5vxl' size='340' side='right'caption='[[5vxl]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='5vxl' size='340' side='right'caption='[[5vxl]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5vxl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXL OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5vxl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VXL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vxl OCA], [https://pdbe.org/5vxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vxl RCSB], [https://www.ebi.ac.uk/pdbsum/5vxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vxl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> |
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Shigella flexneri]] |
| - | [[Category: | + | [[Category: Vicugna pacos]] |
| - | [[Category: | + | [[Category: Barta ML]] |
| - | [[Category: | + | [[Category: Battaile KP]] |
| - | [[Category: | + | [[Category: Lovell S]] |
| - | [[Category: | + | [[Category: Picking WD]] |
| - | [[Category: | + | [[Category: Picking WL]] |
| - | + | ||
| - | + | ||
Current revision
2.80 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JPS-G3
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