5wf5

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Current revision (14:11, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5wf5' size='340' side='right'caption='[[5wf5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5wf5' size='340' side='right'caption='[[5wf5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wf5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WF5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WF5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WF5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=UKA:6-(2,2-DIPHENYLETHYLAMINO)-9-[(2R,3R,4S,5S)-5-(ETHYLCARBAMOYL)-3,4-DIHYDROXY-OXOLAN-2-YL]-N-[2-[(1-PYRIDIN-2-YLPIPERIDIN-4-YL)CARBAMOYLAMINO]ETHYL]PURINE-2-CARBOXAMIDE'>UKA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wf5 OCA], [http://pdbe.org/5wf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wf5 RCSB], [http://www.ebi.ac.uk/pdbsum/5wf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wf5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wf5 OCA], [https://pdbe.org/5wf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wf5 RCSB], [https://www.ebi.ac.uk/pdbsum/5wf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wf5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia virus T4]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Deary A]]
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[[Category: Deary, A]]
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[[Category: Eddy MT]]
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[[Category: Eddy, M T]]
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[[Category: Gao Z]]
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[[Category: Gao, Z]]
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[[Category: Han GW]]
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[[Category: Han, G W]]
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[[Category: Hanson MA]]
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[[Category: Hanson, M A]]
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[[Category: Jacobson KA]]
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[[Category: Jacobson, K A]]
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[[Category: Katritch V]]
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[[Category: Katritch, V]]
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[[Category: Lian T]]
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[[Category: Lian, T]]
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[[Category: Patel N]]
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[[Category: Patel, N]]
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[[Category: Stevens RC]]
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[[Category: Stevens, R C]]
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[[Category: White KL]]
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[[Category: White, K L]]
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[[Category: Activation microswitch]]
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[[Category: Agonist]]
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[[Category: Allosteric na-site mutant]]
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[[Category: D52n]]
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[[Category: Gpcr signaling]]
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[[Category: Gpcr-t4l chimera]]
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[[Category: Human a2a adenosine receptor]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Uk432097]]
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Current revision

Agonist bound human A2a adenosine receptor with D52N mutation at 2.60 A resolution

PDB ID 5wf5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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