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| | <StructureSection load='5wlg' size='340' side='right'caption='[[5wlg]], [[Resolution|resolution]] 2.10Å' scene=''> | | <StructureSection load='5wlg' size='340' side='right'caption='[[5wlg]], [[Resolution|resolution]] 2.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5wlg]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human], [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Plabe Plabe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WLG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5wlg]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WLG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), GAP50, PBK173_000161900, PBNK65E_000154900, PBNK65NY_000154100, PBSP11A_000154100, PBSP11RLL_000154100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5821 PLABE]), B2M, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2M, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wlg OCA], [http://pdbe.org/5wlg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wlg RCSB], [http://www.ebi.ac.uk/pdbsum/5wlg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wlg ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wlg OCA], [https://pdbe.org/5wlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wlg RCSB], [https://www.ebi.ac.uk/pdbsum/5wlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wlg ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/A0A0Y9W4B5_PLABE A0A0Y9W4B5_PLABE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| | + | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Plabe]] | + | [[Category: Plasmodium berghei]] |
| - | [[Category: Farenc, C]] | + | [[Category: Farenc C]] |
| - | [[Category: Gras, S]] | + | [[Category: Gras S]] |
| - | [[Category: Josephs, T]] | + | [[Category: Josephs T]] |
| - | [[Category: Rossjohn, J]] | + | [[Category: Rossjohn J]] |
| - | [[Category: Gap50]]
| + | |
| - | [[Category: H-2db]]
| + | |
| - | [[Category: Immune response gene]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Malaria]]
| + | |
| - | [[Category: T cell]]
| + | |
| - | [[Category: Tcr]]
| + | |
| - | [[Category: Vb8 1]]
| + | |
| Structural highlights
Function
A0A0Y9W4B5_PLABE
Publication Abstract from PubMed
Immune response (Ir) genes, originally proposed by Baruj Benacerraf to explain differential antigen-specific responses in animal models, have become synonymous with the major histocompatibility complex (MHC). We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was required for CD8(+) T cell responses to the Plasmodium berghei GAP5040-48 epitope in mice expressing the MHC class I allele H-2D(b). GAP5040-48-specific CD8(+) T cell responses emerged from a very large pool of naive Vbeta8.1(+) precursors, which dictated susceptibility to cerebral malaria and conferred protection against recombinant Listeria monocytogenes infection. Structural analysis of a prototypical Vbeta8.1(+) TCR-H-2D(b)-GAP5040-48 ternary complex revealed that germline-encoded complementarity-determining region 1beta residues present exclusively in the Vbeta8.1 segment mediated essential interactions with the GAP5040-48 peptide. Collectively, these findings demonstrated that Vbeta8.1 functioned as an Ir gene that was indispensable for immune reactivity against the malaria GAP5040-48 epitope.
A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene.,Van Braeckel-Budimir N, Gras S, Ladell K, Josephs TM, Pewe L, Urban SL, Miners KL, Farenc C, Price DA, Rossjohn J, Harty JT Immunity. 2017 Nov 21;47(5):835-847.e4. doi: 10.1016/j.immuni.2017.10.013. Epub, 2017 Nov 14. PMID:29150238[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Van Braeckel-Budimir N, Gras S, Ladell K, Josephs TM, Pewe L, Urban SL, Miners KL, Farenc C, Price DA, Rossjohn J, Harty JT. A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity. 2017 Nov 21;47(5):835-847.e4. doi: 10.1016/j.immuni.2017.10.013. Epub, 2017 Nov 14. PMID:29150238 doi:http://dx.doi.org/10.1016/j.immuni.2017.10.013
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