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5wlo
From Proteopedia
(Difference between revisions)
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<StructureSection load='5wlo' size='340' side='right'caption='[[5wlo]], [[Resolution|resolution]] 1.27Å' scene=''> | <StructureSection load='5wlo' size='340' side='right'caption='[[5wlo]], [[Resolution|resolution]] 1.27Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wlo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5wlo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WLO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR7:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl+{(2S,3R)-3-hydroxy-4-[(7E)-13-methoxy-1,1-dioxo-1,4,5,6,9,11-hexahydro-10,1lambda~6~,2-benzoxathiazacyclotridecin-2(3H)-yl]-1-phenylbutan-2-yl}carbamate'>GR7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GR7:(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl+{(2S,3R)-3-hydroxy-4-[(7E)-13-methoxy-1,1-dioxo-1,4,5,6,9,11-hexahydro-10,1lambda~6~,2-benzoxathiazacyclotridecin-2(3H)-yl]-1-phenylbutan-2-yl}carbamate'>GR7</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wlo OCA], [https://pdbe.org/5wlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wlo RCSB], [https://www.ebi.ac.uk/pdbsum/5wlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wlo ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q72498_9HIV1 Q72498_9HIV1] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Agniswamy | + | [[Category: Agniswamy J]] |
| - | [[Category: Wang | + | [[Category: Wang Y-F]] |
| - | [[Category: Weber | + | [[Category: Weber IT]] |
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Current revision
a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands
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