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6ar4

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Current revision (14:23, 4 October 2023) (edit) (undo)
 
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==Crystal structure of PICK1 in complex with the small molecule inhibitor 1o==
==Crystal structure of PICK1 in complex with the small molecule inhibitor 1o==
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<StructureSection load='6ar4' size='340' side='right' caption='[[6ar4]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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<StructureSection load='6ar4' size='340' side='right'caption='[[6ar4]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ar4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AR4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ar4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AR4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQA:N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine'>BQA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PICK1, PRKCABP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BQA:N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine'>BQA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ar4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ar4 OCA], [http://pdbe.org/6ar4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ar4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ar4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ar4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ar4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ar4 OCA], [https://pdbe.org/6ar4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ar4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ar4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ar4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref>
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[https://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Marcotte, D]]
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[[Category: Large Structures]]
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[[Category: Actin binding protein]]
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[[Category: Marcotte D]]
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[[Category: Pdz domain pdz inhibitor]]
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Current revision

Crystal structure of PICK1 in complex with the small molecule inhibitor 1o

PDB ID 6ar4

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