6ary

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<StructureSection load='6ary' size='340' side='right'caption='[[6ary]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='6ary' size='340' side='right'caption='[[6ary]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ary]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ARY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ary]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ARY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BT7:(1S)-2,2-difluoro-1-[1-(pentan-3-yl)-1H-pyrazol-4-yl]ethan-1-ol'>BT7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.257&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ace, ACE1, ACHE1, AGAP001356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BT7:(1S)-2,2-difluoro-1-[1-(pentan-3-yl)-1H-pyrazol-4-yl]ethan-1-ol'>BT7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ary FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ary OCA], [https://pdbe.org/6ary PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ary RCSB], [https://www.ebi.ac.uk/pdbsum/6ary PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ary ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ary FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ary OCA], [http://pdbe.org/6ary PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ary RCSB], [http://www.ebi.ac.uk/pdbsum/6ary PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ary ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACES_ANOGA ACES_ANOGA]] Rapidly hydrolyzes choline released into the synapse.
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[https://www.uniprot.org/uniprot/ACES_ANOGA ACES_ANOGA] Rapidly hydrolyzes choline released into the synapse.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
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[[Category: Anopheles gambiae]]
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[[Category: Anoga]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carlier, P R]]
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[[Category: Carlier PR]]
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[[Category: Cheung, J]]
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[[Category: Cheung J]]
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[[Category: Kalathur, R]]
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[[Category: Kalathur R]]
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[[Category: Lixuan, L]]
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[[Category: Lixuan L]]
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[[Category: Mahmood, A]]
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[[Category: Mahmood A]]
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[[Category: Difluoromethyl ketone]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 14:23, 4 October 2023

Crystal structure of an insecticide-resistant acetylcholinesterase mutant from the malaria vector Anopheles gambiae in complex with a difluoromethyl ketone inhibitor

PDB ID 6ary

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