6auj

<StructureSection load='6auj' size='340' side='right' caption='[[6auj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>

<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_anophelis_nuhp1 Elizabethkingia anophelis nuhp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thyA, BD94_0762 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1338011 Elizabethkingia anophelis NUHP1])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [http://pdbe.org/6auj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [http://www.ebi.ac.uk/pdbsum/6auj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO]] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]

[[Category: Elizabethkingia anophelis nuhp1]]

[[Category: Thymidylate synthase]]

[[Category: Transferase]]