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1n8t

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[[Image:1n8t.gif|left|200px]]
[[Image:1n8t.gif|left|200px]]
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{{Structure
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|PDB= 1n8t |SIZE=350|CAPTION= <scene name='initialview01'>1n8t</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1n8t", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase Glucose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 5.3.1.9] </span>
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{{STRUCTURE_1n8t| PDB=1n8t | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n8t OCA], [http://www.ebi.ac.uk/pdbsum/1n8t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n8t RCSB]</span>
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'''The crystal structure of phosphoglucose isomerase from rabbit muscle'''
'''The crystal structure of phosphoglucose isomerase from rabbit muscle'''
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[[Category: Davies, C.]]
[[Category: Davies, C.]]
[[Category: Muirhead, H.]]
[[Category: Muirhead, H.]]
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[[Category: aldose-ketose isomerase]]
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[[Category: Aldose-ketose isomerase]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycolysis]]
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[[Category: Glycolysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:14:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:58 2008''
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Revision as of 23:14, 2 May 2008

Image:1n8t.gif

Template:STRUCTURE 1n8t

The crystal structure of phosphoglucose isomerase from rabbit muscle


Overview

Phosphoglucose isomerase (PGI) is a housekeeping enzyme of metabolism that catalyses the interconversion of glucose 6-phosphate and fructose 6-phosphate, with roles in the glycolytic and gluconeogenic pathways. PGI is also a multifunctional protein that manifests the properties of a cytokine in a wide array of cellular processes, including the production of immunoglobulin by B cells and tumour-cell differentiation. The crystal structure of PGI in the native form from rabbit muscle has been solved at a resolution of 2.5 A by a combination of multiple isomorphous replacement and multi-crystal averaging techniques. Comparison with published structures of rabbit PGI in complex with three inhibitors and with the substrate fructose 6-phosphate reveals a number of conformational changes that may be associated with catalytic function. These occur in the small domain around the sugar phosphate-binding site, in a small helix carrying His388 and in a helix near the C-terminal end. One of these may be the structural rearrangement that has been postulated to be the rate-limiting step for catalysis.

About this Structure

1N8T is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of native phosphoglucose isomerase from rabbit: conformational changes associated with catalytic function., Davies C, Muirhead H, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):453-65. Epub 2003, Feb 21. PMID:12595702 Page seeded by OCA on Sat May 3 02:14:14 2008

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