6bdn

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Current revision (14:38, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6bdn' size='340' side='right'caption='[[6bdn]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6bdn' size='340' side='right'caption='[[6bdn]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bdn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bdn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BDN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdn OCA], [http://pdbe.org/6bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdn RCSB], [http://www.ebi.ac.uk/pdbsum/6bdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdn OCA], [https://pdbe.org/6bdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bdn RCSB], [https://www.ebi.ac.uk/pdbsum/6bdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TAOK3_HUMAN TAOK3_HUMAN]] Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).<ref>PMID:10559204</ref> <ref>PMID:10924369</ref> <ref>PMID:17396146</ref>
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[https://www.uniprot.org/uniprot/TAOK3_HUMAN TAOK3_HUMAN] Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).<ref>PMID:10559204</ref> <ref>PMID:10924369</ref> <ref>PMID:17396146</ref>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Aleshin AE]]
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[[Category: Aleshin, A E]]
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[[Category: Bankton LA]]
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[[Category: Bankton, L A]]
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[[Category: Courtneidge SA]]
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[[Category: Courtneidge, S A]]
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[[Category: Liddington RC]]
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[[Category: Liddington, R C]]
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[[Category: Pinkerton A]]
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[[Category: Pinkerton, A]]
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[[Category: Adt-binding]]
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[[Category: Kinase]]
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[[Category: Mapk cascade]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Taok3]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human TAO3 kinase binding ADP

PDB ID 6bdn

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