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| | <StructureSection load='6bv6' size='340' side='right'caption='[[6bv6]], [[Resolution|resolution]] 2.20Å' scene=''> | | <StructureSection load='6bv6' size='340' side='right'caption='[[6bv6]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6bv6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BV6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bv6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BV6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JUG:5-HYDROXYNAPHTHALENE-1,4-DIONE'>JUG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bv5|6bv5]], [[6bv8|6bv8]], [[6bv9|6bv9]]</td></tr>
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUG:5-HYDROXYNAPHTHALENE-1,4-DIONE'>JUG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRORP1, At2g32230, F22D22.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bv6 OCA], [https://pdbe.org/6bv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bv6 RCSB], [https://www.ebi.ac.uk/pdbsum/6bv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bv6 ProSAT]</span></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bv6 OCA], [http://pdbe.org/6bv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bv6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bv6 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PRRP1_ARATH PRRP1_ARATH]] Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.<ref>PMID:20473316</ref> <ref>PMID:20660484</ref> <ref>PMID:22549728</ref> | + | [https://www.uniprot.org/uniprot/PRRP1_ARATH PRRP1_ARATH] Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.<ref>PMID:20473316</ref> <ref>PMID:20660484</ref> <ref>PMID:22549728</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arath]] | + | [[Category: Arabidopsis thaliana]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Ribonuclease P]]
| + | [[Category: Fierke CA]] |
| - | [[Category: Fierke, C A]] | + | [[Category: Karasik A]] |
| - | [[Category: Karasik, A]] | + | [[Category: Koutmos M]] |
| - | [[Category: Koutmos, M]] | + | [[Category: Wu N]] |
| - | [[Category: Wu, N]] | + | |
| - | [[Category: Chloroplast]]
| + | |
| - | [[Category: Hydrolase-hydrolase inhibitor complex]]
| + | |
| - | [[Category: Metallonuclease]]
| + | |
| - | [[Category: Mitochondria]]
| + | |
| - | [[Category: Nyn domain]]
| + | |
| - | [[Category: Pin]]
| + | |
| - | [[Category: Ppr domain]]
| + | |
| - | [[Category: Prorp]]
| + | |
| - | [[Category: Ribonuclease]]
| + | |
| - | [[Category: Rnase p]]
| + | |
| - | [[Category: Trna processing]]
| + | |
| Structural highlights
Function
PRRP1_ARATH Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria.[1] [2] [3]
References
- ↑ Gobert A, Gutmann B, Taschner A, Gossringer M, Holzmann J, Hartmann RK, Rossmanith W, Giege P. A single Arabidopsis organellar protein has RNase P activity. Nat Struct Mol Biol. 2010 Jun;17(6):740-4. doi: 10.1038/nsmb.1812. Epub 2010 May , 16. PMID:20473316 doi:http://dx.doi.org/10.1038/nsmb.1812
- ↑ Placido A, Sieber F, Gobert A, Gallerani R, Giege P, Marechal-Drouard L. Plant mitochondria use two pathways for the biogenesis of tRNAHis. Nucleic Acids Res. 2010 Nov;38(21):7711-7. doi: 10.1093/nar/gkq646. Epub 2010 Jul, 25. PMID:20660484 doi:http://dx.doi.org/10.1093/nar/gkq646
- ↑ Gutmann B, Gobert A, Giege P. PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis. Genes Dev. 2012 May 15;26(10):1022-7. doi: 10.1101/gad.189514.112. Epub 2012 May , 1. PMID:22549728 doi:http://dx.doi.org/10.1101/gad.189514.112
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