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| | <StructureSection load='6bx7' size='340' side='right'caption='[[6bx7]], [[Resolution|resolution]] 2.85Å' scene=''> | | <StructureSection load='6bx7' size='340' side='right'caption='[[6bx7]], [[Resolution|resolution]] 2.85Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BX7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BX7 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PCDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [http://pdbe.org/6bx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [https://pdbe.org/6bx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [https://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion. | + | [https://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN] May be involved in cell-cell interaction processes and in cell adhesion. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Modak, D]] | + | [[Category: Modak D]] |
| - | [[Category: Sotomayor, M]] | + | [[Category: Sotomayor M]] |
| - | [[Category: Adhesion]]
| + | |
| - | [[Category: Asthma]]
| + | |
| - | [[Category: Cadherin]]
| + | |
| - | [[Category: Calcium-binding protein]]
| + | |
| - | [[Category: Cell adhesion]]
| + | |
| Structural highlights
Function
PCDH1_HUMAN May be involved in cell-cell interaction processes and in cell adhesion.
Publication Abstract from PubMed
Cadherins form a large family of calcium-dependent adhesive proteins involved in morphogenesis, cell differentiation, and neuronal connectivity. Non-clustered delta1 protocadherins form a cadherin subgroup of proteins with seven extracellular cadherin (EC) repeats and cytoplasmic domains distinct from those of classical cadherins. Non-clustered delta1 protocadherins mediate homophilic adhesion and have been implicated in various diseases including asthma, autism, and cancer. Here we present X-ray crystal structures of human Protocadherin-1 (PCDH1), a delta1-protocadherin member essential for New World Hantavirus infection that is typically expressed in the brain, airway epithelium, skin keratinocytes, and lungs. The structures suggest a binding mode that involves antiparallel overlap of repeats EC1 to EC4. Mutagenesis combined with binding assays and biochemical experiments validated this mode of adhesion. Overall, these results reveal the molecular mechanism underlying adhesiveness of PCDH1 and delta1-protocadherins, also shedding light on PCDH1's role in maintaining airway epithelial integrity, the loss of which causes respiratory diseases.
Identification of an adhesive interface for the non-clustered delta1 protocadherin-1 involved in respiratory diseases.,Modak D, Sotomayor M Commun Biol. 2019 Sep 30;2:354. doi: 10.1038/s42003-019-0586-0. eCollection 2019. PMID:31583286[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Modak D, Sotomayor M. Identification of an adhesive interface for the non-clustered delta1 protocadherin-1 involved in respiratory diseases. Commun Biol. 2019 Sep 30;2:354. doi: 10.1038/s42003-019-0586-0. eCollection 2019. PMID:31583286 doi:http://dx.doi.org/10.1038/s42003-019-0586-0
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