1n9e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1n9e.gif|left|200px]]
[[Image:1n9e.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1n9e |SIZE=350|CAPTION= <scene name='initialview01'>1n9e</scene>, resolution 1.65&Aring;
+
The line below this paragraph, containing "STRUCTURE_1n9e", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-lysine_6-oxidase Protein-lysine 6-oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.13 1.4.3.13] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1n9e| PDB=1n9e | SCENE= }}
-
|RELATEDENTRY=[[1oac|1OAC]], [[1av4|1AV4]], [[1a2v|1A2V]], [[1ksi|1KSI]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n9e OCA], [http://www.ebi.ac.uk/pdbsum/1n9e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n9e RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO'''
'''CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO'''
Line 28: Line 25:
[[Category: Duff, A P.]]
[[Category: Duff, A P.]]
[[Category: Guss, J M.]]
[[Category: Guss, J M.]]
-
[[Category: amine oxidase]]
+
[[Category: Amine oxidase]]
-
[[Category: copper]]
+
[[Category: Copper]]
-
[[Category: quinoprotein]]
+
[[Category: Quinoprotein]]
-
[[Category: topaquinone enzyme]]
+
[[Category: Topaquinone enzyme]]
-
[[Category: tpq]]
+
[[Category: Tpq]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:15:31 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:11 2008''
+

Revision as of 23:15, 2 May 2008

Image:1n9e.gif

Template:STRUCTURE 1n9e

CRYSTAL STRUCTURE OF PICHIA PASTORIS LYSYL OXIDASE PPLO


Overview

Pichia pastoris lysyl oxidase (PPLO) is unique among the structurally characterized copper amine oxidases in being able to oxidize the side chain of lysine residues in polypeptides. Remarkably, the yeast PPLO is nearly as effective in oxidizing a mammalian tropoelastin substrate as is a true mammalian lysyl oxidase isolated from bovine aorta. Thus, PPLO is functionally related to the copper-containing lysyl oxidases despite the lack of any significant sequence similarity with these enzymes. The structure of PPLO has been determined at 1.65 A resolution. PPLO is a homodimer in which each subunit contains a Type II copper atom and a topaquinone cofactor (TPQ) formed by the posttranslational modification of a tyrosine residue. While PPLO has tertiary and quaternary topologies similar to those found in other quinone-containing copper amine oxidases, its active site is substantially more exposed and accessible. The structural elements that are responsible for the accessibility of the active site are identified and discussed.

About this Structure

1N9E is a Single protein structure of sequence from Pichia pastoris. Full crystallographic information is available from OCA.

Reference

The crystal structure of Pichia pastoris lysyl oxidase., Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM, Biochemistry. 2003 Dec 30;42(51):15148-57. PMID:14690425 Page seeded by OCA on Sat May 3 02:15:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n9e"
Personal tools