6c6d

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==20mer crystal structure of CC chemokine 5 (CCL5)==
==20mer crystal structure of CC chemokine 5 (CCL5)==
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<StructureSection load='6c6d' size='340' side='right'caption='[[6c6d]]' scene=''>
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<StructureSection load='6c6d' size='340' side='right'caption='[[6c6d]], [[Resolution|resolution]] 5.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6C6D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c6d]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C6D FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6c6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6d OCA], [http://pdbe.org/6c6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6d RCSB], [http://www.ebi.ac.uk/pdbsum/6c6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6d ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6d OCA], [https://pdbe.org/6c6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c6d RCSB], [https://www.ebi.ac.uk/pdbsum/6c6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6d ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liang WG]]
[[Category: Liang WG]]
[[Category: Tang WJ]]
[[Category: Tang WJ]]

Revision as of 14:57, 4 October 2023

20mer crystal structure of CC chemokine 5 (CCL5)

PDB ID 6c6d

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