6c83
From Proteopedia
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<StructureSection load='6c83' size='340' side='right'caption='[[6c83]], [[Resolution|resolution]] 2.55Å' scene=''> | <StructureSection load='6c83' size='340' side='right'caption='[[6c83]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6c83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6c83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C83 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c83 OCA], [https://pdbe.org/6c83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c83 RCSB], [https://www.ebi.ac.uk/pdbsum/6c83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c83 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c83 OCA], [https://pdbe.org/6c83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c83 RCSB], [https://www.ebi.ac.uk/pdbsum/6c83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c83 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/AURKA_HUMAN AURKA_HUMAN] Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.<ref>PMID:9606188</ref> <ref>PMID:11039908</ref> <ref>PMID:11551964</ref> <ref>PMID:12390251</ref> <ref>PMID:13678582</ref> <ref>PMID:14523000</ref> <ref>PMID:15147269</ref> <ref>PMID:14990569</ref> <ref>PMID:15128871</ref> <ref>PMID:14702041</ref> <ref>PMID:15987997</ref> <ref>PMID:18056443</ref> <ref>PMID:17604723</ref> <ref>PMID:17360485</ref> <ref>PMID:18615013</ref> <ref>PMID:19812038</ref> <ref>PMID:19351716</ref> <ref>PMID:19668197</ref> <ref>PMID:19357306</ref> <ref>PMID:20643351</ref> <ref>PMID:17125279</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Synthetic construct]] | |
| - | [[Category: Synthetic construct | + | [[Category: Hoemberger M]] |
| - | [[Category: Hoemberger | + | [[Category: Kern D]] |
| - | [[Category: Kern | + | [[Category: Kutter S]] |
| - | [[Category: Kutter | + | [[Category: Nguyen V]] |
| - | [[Category: Nguyen | + | [[Category: Shohei A]] |
| - | [[Category: Shohei | + | [[Category: Shohei K]] |
| - | [[Category: Shohei | + | [[Category: Zorba A]] |
| - | [[Category: Zorba | + | |
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Current revision
Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP
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Categories: Homo sapiens | Large Structures | Synthetic construct | Hoemberger M | Kern D | Kutter S | Nguyen V | Shohei A | Shohei K | Zorba A
