6cax

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==Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805==
==Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805==
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<StructureSection load='6cax' size='340' side='right' caption='[[6cax]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='6cax' size='340' side='right'caption='[[6cax]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cax]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CAX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EUY:(2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}butanamide'>EUY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5upg|5upg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EUY:(2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}butanamide'>EUY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cax OCA], [https://pdbe.org/6cax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cax RCSB], [https://www.ebi.ac.uk/pdbsum/6cax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cax ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cax OCA], [http://pdbe.org/6cax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cax RCSB], [http://www.ebi.ac.uk/pdbsum/6cax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cax ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPXC_PSEA8 LPXC_PSEA8]] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
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[https://www.uniprot.org/uniprot/LPXC_PSEA8 LPXC_PSEA8] Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
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==See Also==
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*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Lipid a biosynthesis]]
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[[Category: Lpxc]]
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[[Category: Ssgcid]]
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Current revision

Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805

PDB ID 6cax

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