6cd6

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Current revision (15:01, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6cd6' size='340' side='right'caption='[[6cd6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6cd6' size='340' side='right'caption='[[6cd6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cd6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CD6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CD6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAMKK1, CAMKKA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cd6 OCA], [https://pdbe.org/6cd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cd6 RCSB], [https://www.ebi.ac.uk/pdbsum/6cd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cd6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cd6 OCA], [http://pdbe.org/6cd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cd6 RCSB], [http://www.ebi.ac.uk/pdbsum/6cd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cd6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN]] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
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[https://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arruda, P]]
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[[Category: Arruda P]]
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[[Category: Counago, R M]]
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[[Category: Counago RM]]
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[[Category: Drewry, D]]
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[[Category: Drewry D]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M]]
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[[Category: Elkins JM]]
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[[Category: Massirer, K B]]
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[[Category: Massirer KB]]
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[[Category: Ramos, P Z]]
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[[Category: Ramos PZ]]
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[[Category: Righetto, G L]]
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[[Category: Righetto GL]]
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[[Category: Structural genomic]]
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[[Category: Santiago AS]]
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[[Category: Santiago, A S]]
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[[Category: Silva PNB]]
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[[Category: Silva, P N.B]]
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[[Category: Protein kinase domain]]
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[[Category: Sgc]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of the Human CAMKK1A in complex with GSK650394

PDB ID 6cd6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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