6cdu

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Current revision (15:01, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6cdu' size='340' side='right'caption='[[6cdu]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
<StructureSection load='6cdu' size='340' side='right'caption='[[6cdu]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cdu]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CDU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cdu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_dadantii_3937 Dickeya dadantii 3937] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CDU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EY4:(3a,5a)-3-Hydroxypregnane-11,20-dione'>EY4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EY4:(3a,5a)-3-Hydroxypregnane-11,20-dione'>EY4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cdu OCA], [http://pdbe.org/6cdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cdu RCSB], [http://www.ebi.ac.uk/pdbsum/6cdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cdu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cdu OCA], [https://pdbe.org/6cdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cdu RCSB], [https://www.ebi.ac.uk/pdbsum/6cdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cdu ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Juvenile myoclonic epilepsy;Childhood absence epilepsy;Dravet syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/E0SJQ4_DICD3 E0SJQ4_DICD3] [https://www.uniprot.org/uniprot/GBRA1_HUMAN GBRA1_HUMAN] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6cdu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6cdu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[GABA receptor 3D structures|GABA receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Dickeya dadantii 3937]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arjunan, P]]
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[[Category: Arjunan P]]
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[[Category: Chen, Q]]
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[[Category: Chen Q]]
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[[Category: Cohen, A E]]
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[[Category: Cohen AE]]
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[[Category: Tang, P]]
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[[Category: Tang P]]
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[[Category: Xu, Y]]
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[[Category: Xu Y]]
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[[Category: Alphaxalone]]
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[[Category: Anesthetic]]
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[[Category: Gabaa receptor]]
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[[Category: Neurosteroid]]
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[[Category: Protein transport]]
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Current revision

Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone

PDB ID 6cdu

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