6co1

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Current revision (15:08, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6co1' size='340' side='right'caption='[[6co1]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='6co1' size='340' side='right'caption='[[6co1]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6co1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CO1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6co1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CO1 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT16L1, SDOS, TIRR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TP53BP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.179&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co1 OCA], [http://pdbe.org/6co1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6co1 RCSB], [http://www.ebi.ac.uk/pdbsum/6co1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6co1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6co1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6co1 OCA], [https://pdbe.org/6co1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6co1 RCSB], [https://www.ebi.ac.uk/pdbsum/6co1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6co1 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN]] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref> [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[https://www.uniprot.org/uniprot/TIRR_HUMAN TIRR_HUMAN] Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).<ref>PMID:18820299</ref> <ref>PMID:28241136</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Botuyan, M V]]
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[[Category: Botuyan MV]]
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[[Category: Cui, G]]
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[[Category: Cui G]]
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[[Category: Mer, G]]
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[[Category: Mer G]]
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[[Category: Dna damage response]]
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[[Category: Dna damage signaling]]
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[[Category: Dna repair]]
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[[Category: Nudt16l1]]
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[[Category: Protein binding]]
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[[Category: Tirr]]
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Current revision

Structure of human TIRR in complex with 53BP1 Tudor domains

PDB ID 6co1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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