1na0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1na0.jpg|left|200px]]
[[Image:1na0.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1na0 |SIZE=350|CAPTION= <scene name='initialview01'>1na0</scene>, resolution 1.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_1na0", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPT:ISOPROPYL-1-BETA-D-THIOGALACTOSIDE'>IPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1na0| PDB=1na0 | SCENE= }}
-
|RELATEDENTRY=[[1na3|1NA3]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1na0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1na0 OCA], [http://www.ebi.ac.uk/pdbsum/1na0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1na0 RCSB]</span>
+
-
}}
+
'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif'''
'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1NA0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA0 OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA0 OCA].
==Reference==
==Reference==
Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816]
Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12737816 12737816]
-
[[Category: ]]
 
-
[[Category: Protein complex]]
 
[[Category: Andrea, L D.]]
[[Category: Andrea, L D.]]
[[Category: Cocco, M.]]
[[Category: Cocco, M.]]
Line 30: Line 25:
[[Category: Regan, L.]]
[[Category: Regan, L.]]
[[Category: Xiong, Y.]]
[[Category: Xiong, Y.]]
-
[[Category: design]]
+
[[Category: Design]]
-
[[Category: tpr]]
+
[[Category: Tpr]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:16:48 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:27 2008''
+

Revision as of 23:16, 2 May 2008

Image:1na0.jpg

Template:STRUCTURE 1na0

Design of Stable alpha-Helical Arrays from an Idealized TPR Motif


Overview

The tetratricopeptide repeat (TPR) is a 34-amino acid alpha-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resolution X-ray crystal structures (to 1.55 and 1.6 A) of designed TPR proteins and describe their solution properties and stability. A detailed analysis of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs.

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:12737816 Page seeded by OCA on Sat May 3 02:16:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1na0"
Personal tools