3ano

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<StructureSection load='3ano' size='340' side='right'caption='[[3ano]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='3ano' size='340' side='right'caption='[[3ano]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ano]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ano]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.894&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT2688, Rv2613c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ATP_adenylyltransferase ATP adenylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.53 2.7.7.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ano OCA], [https://pdbe.org/3ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ano RCSB], [https://www.ebi.ac.uk/pdbsum/3ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ano ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ano OCA], [https://pdbe.org/3ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ano RCSB], [https://www.ebi.ac.uk/pdbsum/3ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ano ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU]] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
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[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ATP adenylyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Arakawa, Y]]
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[[Category: Arakawa Y]]
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[[Category: Mori, S]]
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[[Category: Mori S]]
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[[Category: Shibayama, K]]
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[[Category: Shibayama K]]
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[[Category: Wachino, J]]
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[[Category: Wachino J]]
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[[Category: Diadenosine polyphosphate]]
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[[Category: Hit motif]]
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[[Category: Mycobacterium]]
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[[Category: Phosphorylase]]
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[[Category: Transferase]]
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Revision as of 15:49, 4 October 2023

Crystal Structure of a Novel Diadenosine 5',5-P1,P4-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv

PDB ID 3ano

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