1nam

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[[Image:1nam.gif|left|200px]]
[[Image:1nam.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1nam |SIZE=350|CAPTION= <scene name='initialview01'>1nam</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1nam", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1nam| PDB=1nam | SCENE= }}
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|RELATEDENTRY=[[1fo0|1FO0]], [[1kj3|1KJ3]], [[2vaa|2VAA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nam OCA], [http://www.ebi.ac.uk/pdbsum/1nam PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nam RCSB]</span>
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}}
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'''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX'''
'''MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX'''
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[[Category: Mosser, T.]]
[[Category: Mosser, T.]]
[[Category: Reiser, J B.]]
[[Category: Reiser, J B.]]
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[[Category: alloreactivity]]
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[[Category: Alloreactivity]]
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[[Category: class i mhc]]
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[[Category: Class i mhc]]
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[[Category: crossreactivity]]
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[[Category: Crossreactivity]]
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[[Category: h-2kb]]
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[[Category: H-2kb]]
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[[Category: t cell receptor]]
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[[Category: T cell receptor]]
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[[Category: tcr-pmhc complex]]
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[[Category: Tcr-pmhc complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:17:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:40 2008''
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Revision as of 23:17, 2 May 2008

Image:1nam.gif

Template:STRUCTURE 1nam

MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX


Overview

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these structures showed that the BM3.3 TCR complementarity-determining region (CDR) 3alpha could undergo rearrangements to adapt to structurally different peptide residues. Therefore, CDR3 loop flexibility helps explain TCR binding cross-reactivity.

About this Structure

1NAM is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

CDR3 loop flexibility contributes to the degeneracy of TCR recognition., Reiser JB, Darnault C, Gregoire C, Mosser T, Mazza G, Kearney A, van der Merwe PA, Fontecilla-Camps JC, Housset D, Malissen B, Nat Immunol. 2003 Mar;4(3):241-7. Epub 2003 Feb 3. PMID:12563259 Page seeded by OCA on Sat May 3 02:17:56 2008

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OCA

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