3ara

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='3ara' size='340' side='right'caption='[[3ara]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3ara' size='340' side='right'caption='[[3ara]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ara]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARA FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ara]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARA FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MKH:1-[3-({(2R)-2-[HYDROXY(DIPHENYL)METHYL]PYRROLIDIN-1-YL}SULFONYL)PROPYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>MKH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hqu|2hqu]], [[3ehw|3ehw]], [[1q5h|1q5h]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MKH:1-[3-({(2R)-2-[HYDROXY(DIPHENYL)METHYL]PYRROLIDIN-1-YL}SULFONYL)PROPYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>MKH</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [https://pdbe.org/3ara PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [https://www.ebi.ac.uk/pdbsum/3ara PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ara ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [https://pdbe.org/3ara PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [https://www.ebi.ac.uk/pdbsum/3ara PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ara ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>
+
[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 27: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: DUTP diphosphatase]]
+
[[Category: Chong KT]]
-
[[Category: Chong, K T]]
+
[[Category: Fukuoka M]]
-
[[Category: Fukuoka, M]]
+
[[Category: Miyahara S]]
-
[[Category: Miyahara, S]]
+
[[Category: Miyakoshi H]]
-
[[Category: Miyakoshi, H]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Magnesium binding]]
+

Revision as of 15:52, 4 October 2023

Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors

PDB ID 3ara

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools