3atq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:54, 4 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3atq' size='340' side='right'caption='[[3atq]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3atq' size='340' side='right'caption='[[3atq]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3atq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33909 Atcc 33909]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATQ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3atq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATQ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C14:TETRADECANE'>C14</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3atr|3atr]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C14:TETRADECANE'>C14</scene>, <scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Saci_0986 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2285 ATCC 33909])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atq OCA], [https://pdbe.org/3atq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atq RCSB], [https://www.ebi.ac.uk/pdbsum/3atq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atq OCA], [https://pdbe.org/3atq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atq RCSB], [https://www.ebi.ac.uk/pdbsum/3atq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atq ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GGR_SULAC GGR_SULAC] Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Is not active with NADPH or NADH as an electron donor; the physiological reducing agent is unknown. Is also active on the more upstream precursors of membrane lipid biosynthesis, catalyzing the complete reduction of 3-O-geranylgeranylglyceryl phosphate (GGGP) to 3-O-phytanylglyceryl phosphate, and the partial reduction of geranylgeranyl diphosphate (GGPP) to phytyl diphosphate, thus reducing three of four GGPP double bonds and preserving the allylic double bond (at position 2). This reaction product is a reactive prenyl donor, which can be used as a substrate by archaeal prenyltransferases such as GGGP synthases.<ref>PMID:18375567</ref> <ref>PMID:21515284</ref> <ref>PMID:24954619</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 33909]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Fujihashi, M]]
+
[[Category: Sulfolobus acidocaldarius]]
-
[[Category: Hemmi, H]]
+
[[Category: Fujihashi M]]
-
[[Category: Miki, K]]
+
[[Category: Hemmi H]]
-
[[Category: Murakami, M]]
+
[[Category: Miki K]]
-
[[Category: Sasaki, D]]
+
[[Category: Murakami M]]
-
[[Category: Yoshimura, T]]
+
[[Category: Sasaki D]]
-
[[Category: 3-di-o-geranylgeranylglyceryl phosphate]]
+
[[Category: Yoshimura T]]
-
[[Category: Archaeal membrane precursor]]
+
-
[[Category: Like 2]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Saturating double bond]]
+

Current revision

Geranylgeranyl Reductase (GGR) from Sulfolobus acidocaldarius

PDB ID 3atq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools